CBD Oil Benefits Substantiated by Evidence-Based Research – Article, Infographic & Video
The 8 key CBD Oil Benefits from the top research sources on the topic are summarised in this article, infographic and video. Last updated: June 2017.
Marijuana. The term induces a lot of infamous attention even though its medicinal values can only be matched by a handful of other plants like alfalfa, sage and wild quinine. The medicinal use of marijuana in cannabis oil preparations has been prevalent for centuries. The alarms over the perils of misuse led to the outlawing of marijuana in the 1920s in most of Europe and USA. The medical use of cannabis is still a constitutional crime in many countries.
In recent years, the healing power of marijuana and its chemically allied compounds have brought them back to the spotlight. One of them is a cannabinoid called Cannabidiol, also referred to as CBD, a compound found in cannabis or marijuana that is scientifically proven to support the treatment various diseases. The clinical potential of CBD Oil is at last being effusively explored, because of its non-toxicity and positive side effects.
What is CBD Oil? Non-psychoactive cannabinoid also called Cannabidiol
Cannabis has hundreds of compounds and CBD is one of them, categorised under the class of ingredients ‘cannabinoids’ and also called Cannabidiol. CBD has a high concentration in cannabis and possesses many therapeutical benefits that have been proven clinically. In essence, CBD Oil is a chief non-psychoactive component of Cannabis Sativa.
According to a 2013 study published in the British Journal of Clinical Pharmacology, CBD Oil benefits include performing as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent in experimental models. CBD Oil is, therefore, an effective supplement for the treatment of neural inflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia.
Research is beginning to show that CBD Oil is different to other well-studied cannabinoids. All cannabinoids act as ligands, meaning they dock onto the binding site of a protein and have the ability to modulate a receptor’s behaviour. CB1 receptors are widely distributed but are particularly abundant in areas of the brain, including those concerned with movement, coordination, pain and sensory perception, emotion, memory, cognition, autonomic and endocrine functions.
CB2 receptors are found mostly in the immune system, and they seem to reduce inflammation and certain kinds of pain. Although cannabinoids all have similar structures, they display a wide array of actions at each of the different receptors.
Both CBD1 and CBD2 receptors are activated when consuming pure CBD Oil (more on what the highest-quality CBD oil is at the end of this article).
8 Proven Benefits of CBD Oil
One of the top benefits of CBD oil is it acts as a natural pain-relieving agent. Evidence-based research shows that cannabinoids may be beneficial in pain relief by impeding neuronal transmission in pain pathways. A key Canadian meta-analysis in 2007 proved that the amalgamation of CBD and THC in an oral spray was effective in reducing neuropathic pain and potentially helpful to 50-70% of MS patients. (11)
The Journal of Experimental Medicine published a study in 2012 that proved that CBD halted chronic inflammatory and neuropathic pain considerably in rodents without instigating analgesic tolerance. Ever since medical scientists proposed that CBD and other non-psychoactive constituents of marijuana can be a unique class of therapeutic agents for the management of chronic pain. (8)
Neuroprotective and effective against seizures and nausea
Numerous research findings confirm that CBD Oil produces antipsychotic effects. It seems to have a pharmacological profile analogous to that of different antipsychotic drugs used to study behaviour and neurochemical pathways. It is verified to prevent human experimental psychosis with a remarkable safety profile and has been used for treating patients with schizophrenia and proven effective in open case reports and clinical trials.
Nausea and vomiting can be reduced with the use of CBD Oil. Research in animal studies has proven that both non-intoxicant CBD and intoxicant THC, out of over 80 cannabinoid compounds constituted in marijuana, aid in the suppression of nausea and vomiting. In a 2012 study published in the British Journal of Pharmacology, the benefits of CBD Oil consisted mainly of having antinausea and antiemetic effects when tested on rats. Nonetheless, it is seen that CBD Oil acts in a biphasic manner, implying that when taken in low doses it subdues toxin-induced vomiting, but in larger doses, it has no effect on nausea. (10, 11)
A 2014 assessment piloted by scholars at Stanford University was open to parents from a Facebook group devoted to sharing facts about the use of cannabidiol-enhanced cannabis to treat their children’s seizures. CBD-enriched cannabis was proven effective in the treatment of epilepsy. 11 percent informed the group of no seizures, 42 percent conveyed a better than 80 percent decrease in seizure frequency, and 32 percent informed a 25–60 percent seizure rate fall. Other helpful effects were improved alertness, mood and sleep, while side effects involved lethargy and weakness.
Late in 2014, a different programme saw patients use a purified 98 percent oil-based CBD extract called Epidiolex, which after 3 months of usage proved 39 percent saw more than a 50 percent fall in seizures and a total 32 percent average reduction. These initial results back the animal studies and review reports that CBD Oil may be an effective adjunct for treatment-resistant epilepsy and has been reported to be well tolerated in doses up to 25 milligrammes per kilogramme of body weight. (3, 4)
A study in 2006 inferred that CBD Oil considerably lowered the prevalence of diabetes in non-obese diabetic mice from a rate of 86% in non-treated mice to 30% in CBD-treated mice. Another major benefit of CBD Oil is the substantial reduction of plasma levels of pro-inflammatory cytokines. The CBD-treated mice showed pointedly reduced insulitis after a histological analysis of their pancreatic islets. The American Journal of Medicine published a study in 2013 emphasising the influence of marijuana use on glucose, insulin and insulin resistance amongst US adults. 4,657 adult men and women from the National Health and Nutritional Examination Survey were incorporated in the study from 2005 to 2010. 579 of the partakers were present-day marijuana users and 1,975 were past users. The research study revealed present marijuana users were linked with 16% lower fasting insulin levels than the others. A link between marijuana use and smaller waist circumference was concluded. (12)
In 2013, the British Journal of Clinical Pharmacology reports that CBD Oil safeguards against the vascular impairment caused by a high-glucose diet, swelling or the initiation of type 2 diabetes in animal models. CBD Oil is also proven to decrease vascular hyperpermeability. (8)
Immune-Modulator and Anti-Ageing Supplement
The immunomodulatory effects of the ECS show that optimum levels of CBD Oil can reduce inflammatory responses in patients with autoimmune diseases and promote whole-body well-being. This has turned CBD Oil into the latest anti-ageing supplement with numerous proponents like Dr Robert Melamede and Dr John Hicks, MD, who recommends 5mg/day to his patients as a preventative supplement. (1)
The endocannabinoid system, or ECS, is a signalling network in the human body that has attracted the attention of medical researchers because of its effects on the body’s immune response. Many research studies prove the effects of the ECS on metabolic health, blood-sugar regulation, obesity, pain sensation, oxidative stress, thermoregulation, eye health, mood, memory, and more, but its effect on the immune system has been most remarkable. (2, 5)
Some scientific reports establish that CBD Oil can possess anti-proliferative, pro-apoptotic effects that impede cancer cell migration, adhesion and incursion. A 2006 study put out in the Journal of Pharmacology and Experimental Therapeutics found for the first time that CBD Oil effectively and selectively subdued the progression of diverse breast tumour cell lines and displayed less potency in non-cancer cells.
In 2011, investigators explained the cellular mechanism over which CBD prompts cell death in breast cancer cells. They disclosed that CBD Oil encouraged a concentration-dependent apoptosis (cell death) of both oestrogen receptor-positive and oestrogen receptor-negative breast cancer cells. They also discovered that the actual concentrations of CBD in tumour cells have a minute effect on non-tumorigenic, mammary cells.
CBD Oil works as a non-toxic composite and studies indicate that doses of 700 milligrammes per day for 6 weeks did not display any toxicity in humans, signifying that it can be used for sustained treatment. Not only does the study demonstrate that CBD aids take account of being effective to combat breast cancer cells, but also that it can be used to constrain the incursion of lung and colon cancer. It also holds anti-tumour properties in gliomas and has been used to as an adjunct in leukaemia. (6)
The anxiolytic-like effect of CBD Oil or Cannabidiol has revealed to ease symptoms in patients with social anxiety disorder and scientists recommend that it can also be operative for panic disorder, obsessive-compulsive disorder (OCD), social anxiety disorder and post-traumatic stress disorder. (9)
A 2011 case study intended to equate the effects of a public speaking test on patients with social anxiety disorder. The 24 never-treated patients with social anxiety disorder were given either CBD Oil or placebo 1.5 hours before the test. Scholars established that pre-treatment with CBD Oil reduced anxiety, cognitive impairment and distress in their speech performance, and meaningfully improved the eagerness of their speech. The placebo group showed greater anxiety, cognitive impairment and discomfort. (13)
Legal and Safe
Today, CBD Oil is a legal supplement for humans and pets and it is vegan, non-addictive, non-toxic and non-psychoactive. Please note, CBD Oil must not contain any traces of THC when used on pets.
How to Recognise High-Quality CBD Oil?
When looking for a high-quality CBD Oil for total benefits choose a 100% pure, additive-free, brand that is certified organic (free of toxins, fertilisers, pesticides). Choose cold-pressed or CO2 extraction methods for whole-plant integrity and for all its nutrients to work together on the endocannabinoid system (ECS) system. This whole-pant effect is also called the entourage effect. Avoid heat extraction methods that may be cheaper, but destroy the nutrients and integrity of the plant. Also, ensure the brand has been third-party tested to ensure the marketing claims are real.
We recommend these high-quality CBD Oil brands.
What is the right CBD Oil dosage?
Depends entirely on how concentrated the extract is and your individual circumstances (weight, state of health, etc.). Please follow the suggested CBD Oil dosage on the label of the product you purchase. As a rule of thumb, always start with a lower dosage and see how your body responds. For pets, the ratio of CBD Oil is lower than for humans, that is why there is a specific, veterinarian-formulated Pet CBD Oil Formula.
Conclusions on the Benefits of CBD Hemp Oil
- CBD Oil or Cannabidiol is one of the hundreds of compounds found in cannabis that fit into a class of ingredients called cannabinoids; it is the chief non-psychoactive constituent ofCannabis Sativa.
- Numerous studies show that CBD acts as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic and antipsychotic agent, and is hence an impending supplement for neural inflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia.
- CBD is also being used to decrease the intoxicating effects of THC, such as paranoia and memory impairment.
- High-quality CBD Oil is a certified organic, cold-pressed or CO2 extraction methods for whole-plant integrity and to achieve the entourage effect.
Research Papers and Online References
- Downer EJ. (2011). Cannabinoids and innate immunity: Taking a toll on neuroinflammation. The Scientific World Journal. 11: 855-865.
- Klein TW, et al. (2003). The cannabinoid system and immune modulation. 74: 486-496.
- Maa, Edward; Figi, Paige (2014). “The case for medical marijuana in epilepsy”. Epilepsia. 55 (6): 783–786.
- Melville, Nancy A. (August 14, 2013), Seizure Disorders Enter Medical Marijuana Debate, Medscape Medical News, retrieved January 14, 2014
- Tanasescu R and CS Constantinescu. (2010). Cannabinoids and the immune system: An overview. Immunobiology. 215: 588-597.
- Throckmorton, Douglas (June 24, 2015). “Cannabidiol: Barriers to Research and Potential Medical Benefits”. FDA. Retrieved June 7, 2017.
- Welty, Timothy E.; Luebke, Adrienne; Gidal, Barry E. (September 2014). “Cannabidiol: Promise and Pitfalls”. Epilepsy Currents. 14 (5): 250–252
- Cannabidiol, or CBD, Benefits for Pain, Mental Illness & Anxiety [Web log post]. (n.d.). Retrieved June 9, 2017.
- CBD oil: Uses, health benefits, and risks [Web log post]. (n.d.). Retrieved June 9, 2017.
- 6 Benefits of CBD Oil [Web log post]. (n.d.). Retrieved June 9, 2017.
- 24 Surprising Health Benefits of CBD Oil (Cannabidiol) [Web log post]. (n.d.). Retrieved June 9, 2017.
- A Primer About Cannabidiol And The Benefits Of CBD [Web log post]. (n.d.). Retrieved June 9, 2017.
- 10 Little-Known Uses for CBD [Web log post]. (n.d.). Retrieved June 9, 2017.
- Top 5 Amazing CBD Oil Effects (& Benefits) [Web log post]. (n.d.). Retrieved June 9, 2017.
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